| Final | | time | | | 1. Léa Sprunger |  Switzerland | 51.61s | WL | | 2. Cynthia Bolingo Mbongo |  Belgium | 51.62s | NR | | 3. Lisanne de Witte |  Netherlands | 52.34s | PB | | 4. Agnė ŀerkšnienė |  Lithuania | 52.40s | | | 5. Raphaela Boaheng Lukudo |  Italy | 52.48s | PB | | 6. Justyna Święty-Ersetic |  Poland | 52.64s | |
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| World Indoor, European and Championship Record: Jarmila Kratochvílová 49.59s Milan, Italy | 7 March 1982 | | World and European Leading: Antonina Krivoshapka 51.86s Moscow, Russia 3 February 2019 |
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| | First 2 from each Semi advanced to Final. |
| Semi 1 | | time | | | 6. Raphaela Boaheng Lukudo | Italy | 52.80s | Q, PB | | 7. Justyna Święty-Ersetic | Poland | 52.85s | Q | | 8. Laura Bueno |  Spain | 53.05s | | | 9. Anna Ryzhykova |  Ukraine | 53.22s | | | 13.Agnès Raharolahy |  France | 53.43s | | | 14.Gunta Vaičule |  Latvia | 53.53s | |
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| Semi 2 | | time | | | 1. Léa Sprunger | Switzerland | 51.90s | Q | | 2. Agnė ŀerkšnienė | Lithuania | 52.33s | Q, NR | | 15.Phil Healy |  Ireland | 53.65s | | | 16.Iga Baumgart-Witan | Poland | 53.83s | | | 17.Amandine Brossier | France | 54.56s | | | 18.Ayomide Folorunso | Italy | 57.96s | |
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| Semi 3 | | time | | | 3. Cynthia Bolingo Mbongo | Belgium | 52.37s | Q, NR | | 4. Lisanne de Witte | Netherlands | 52.38s | Q, PB | | 5. Polina Miller |  AN Athletes | 52.46s | PB | | 10.Eilidh Doyle |  Great Britain | 53.28s | | | 11.Déborah Sananes | France | 53.34s | | | 12.Anita Horvat |  Slovenia | 53.37s | |
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| | | First 2 from each Heat and next Best 4 advanced to Semi-Finals. |
| Heat 1 | | time | | | 21.Amandine Brossier | France | 53.40s | Q | | 25.Anita Horvat | Slovenia | 53.53s | Q | | 27.Kateryna Klymyuk | Ukraine | 53.68s | PB | | 28.Maja Ćirić |  Serbia | 53.73s | | | 30.Zoey Clark | Great Britain | 53.85s | | | 37.Salma Paralluelo | Spain | 55.30s | |
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| Heat 2 | | time | | | 15.Iga Baumgart-Witan | Poland | 53.17s | Q | | 16.Agnès Raharolahy | France | 53.21s | Q | | 17.Amber Anning | Great Britain | 53.26s | | | 19.Nadine Gonska |  Germany | 53.38s | | | 34.Sophie Becker | Ireland | 53.99s | |
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| Heat 3 | | time | | | 10.Raphaela Boaheng Lukudo | Italy | 52.99s | Q, SB | | 12.Déborah Sananes | France | 53.05s | Q | | 13.Phil Healy | Ireland | 53.13s | q | | 20.Tetyana Melnyk | Ukraine | 53.39s | | | 31.Andrea Miklos |  Romania | 53.87s | SB | | 32.Evelín Nádházy |  Hungary | 53.90s | |
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| Heat 4 | | time | | | 4. Justyna Święty-Ersetic | Poland | 52.64s | Q | | 7. Anna Ryzhykova | Ukraine | 52.73s | Q, PB | | 8. Ayomide Folorunso | Italy | 52.75s | q | | 29.Yasmin Giger | Switzerland | 53.84s | | | 36.Susanne Walli |  Austria | 54.69s | |
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| Heat 5 | | time | | | 1. Léa Sprunger | Switzerland | 52.46s | Q | | 5. Gunta Vaičule | Latvia | 52.66s | Q, NR | | 6. Laura Bueno | Spain | 52.67s | q, PB | | 33.Matilda Hellqvist |  Sweden | 53.93s | PB | | 35.Iveta Putalová |  Slovakia | 54.19s | |
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| Heat 6 | | time | | | 11.Polina Miller | AN Athletes | 53.03s | Q, PB | | 14.Agnė ŀerkšnienė | Lithuania | 53.14s | Q | | 18.Lada Vondrová |  Czechia | 53.29s | | | 22.Cátia Azevedo |  Portugal | 53.43s | SB | | 24.Eleni Artymata |  Cyprus | 53.49s | PB |
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| Heat 7 | | time | | | 2. Lisanne de Witte | Netherlands | 52.56s | Q, SB | | 3. Cynthia Bolingo Mbongo | Belgium | 52.60s | Q, NR | | 9. Eilidh Doyle | Great Britain | 52.81s | q | | 23.Aauri Lorena Bokesa | Spain | 53.45s | | | 26.Irini Vasiliou |  Greece | 53.66s | |
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